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The bellow is colloquium schedule in Physics department. Every Wednesday 4:00 PM, colloquium is held in seminar room (Science Building III -201) Also, Free tea time will be held 30 minutes before colloquium stars. Please visit and enjoy the colloquium and tea time.
Colloquium 장소 및 시간: 세미나실(공학3동 201호) 오후 4시
연락처 : 물리학과 김지훈교수 (279-2077), firstname.lastname@example.org
물리학과 사무실 김수경 (279-5971) email@example.com
|Distinct Role of Water in Biomolecular Interactions|
speaker : Prof. Sihyun Ham[Sookmyung Women]
date : 2014-11-19
Understanding the molecular determinants of the relative propensity for proteins to aggregate in a cellular environment has been a central issue in attacking proteinaggregation diseases and in the development of human therapeutics. Despite the expectation that the protein aggregation can largely be attributed to the direct proteinprotein interactions within an aggregate or in solution, we here unveil a crucial role of hydration water in ruling the aggregation propensity of proteins both in vitro and in vivo. The protein overall hydrophobicity, defined solely by the hydration free energy of a protein in its monomeric state sampling its equilibrium structures, was shown to predominantly dictate the protein aggregation propensity in aqueous solutions. We also find striking discrimination by the hydration water of positively and negatively charged residues depending on the protein net charge in regulating the solubility of a protein, which establishes novel design strategies for the biotechnological generation of aggregation-resistant proteins as biotherapeutics.